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Article

Disulfide bonds of phospholipase A2 from bee venom yield discrete contributions to its conformational stability.

Biochimie - 1 Feb 2011

Welker Sylvia, Markert Yvonne, Köditz Jens, Mansfeld Johanna, Ulbrich-Hofmann Renate

Abstract excerpt

Disulfide bonds are known to be crucial for protein stability. To probe the contribution of each of the five disulfide bonds (C9-C31, C30-C70, C37-C63, C61-C95, and C105-C113) in bee venom phospholipase A(2) to stability, variants with deleted disulfide bonds were produced by substituting two serine residues for each pair of cysteine residues. The mutations started from the pseudo-wild-type variant (pWT) with the...

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Identifiers

PMID: 20884319
DOI: 10.1016/j.biochi.2010.09.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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