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Article

Impact of an easily reducible disulfide bond on the oxidative folding rate of multi-disulfide-containing proteins.

The journal of peptide research : official journal of the American Peptide Society - 1 Jan 2005

Leung H J, Xu G, Narayan M, Scheraga H A

Abstract excerpt

The burial of native disulfide bonds, formed within stable structure in the regeneration of multi-disulfide-containing proteins from their fully reduced states, is a key step in the folding process, as the burial greatly accelerates the oxidative folding rate of the protein by sequestering the native disulfide bonds from thiol-disulfide exchange reactions. Nevertheless, several proteins retain solvent-exposed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15686534
DOI: 10.1111/j.1399-3011.2004.00189.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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