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Article

Folding and unfolding kinetics of the proline-to-alanine mutants of bovine pancreatic ribonuclease A.

Biochemistry - 6 Feb 1996

Dodge R W, Scheraga H A

Abstract excerpt

Four single mutants (P42A, P93A, P114A, and P117A) of bovine pancreatic ribonuclease A (RNase A) in which each mutant has one of the four prolines of RNase A changed to alanine were prepared. The physical properties of these four mutants indicate that their native structure is essentially identical to that of wild-type RNase A. The disulfide-intact forms of these proteins were denatured in guanidine hydrochloride...

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Identifiers

PMID: 8634286
DOI: 10.1021/bi952348q

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Folding and unfolding kinetics of the proline-to-alanine mutants of bovine pancreatic ribonuclease A.PMID 8634286Read ↗

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