Article
Aglycosylated and phosphatidylinositol-anchored MHC class I molecules are associated with calnexin. Evidence implicating the class I-connecting peptide segment in calnexin association.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 1995
Carreno B M, Schreiber K L, McKean D J, Stroynowski I, Hansen T H
Abstract excerpt
The endoplasmic reticulum resident protein calnexin interacts with several glycoproteins including class I MHC molecules. Calnexin is thought to retain free class I heavy chains and/or promote their folding and assembly with beta 2-microglobulin and peptide ligand. Whereas with other glycoprotein...
Topics
- Amino Acid Sequence
- Animals
- Blotting, Western
- Calcium-Binding Proteins
- Calnexin
- Glycoproteins
- Glycosylation
- Histocompatibility Antigens Class I
- L Cells
- Mice
- Molecular Sequence Data
- Mutation
- Phosphatidylinositols
- Precipitin Tests
- Protein Conformation