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Article

Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients.

Science (New York, N.Y.) - 29 May 1998

de Jong R, Altare F, Haagen I A, Elferink D G, Boer T, van Breda Vriesman P J, Kabel P J, Draaisma J M, van Dissel J T, Kroon F P, Casanova J L, Ottenhoff T H

Abstract excerpt

Interleukin-12 (IL-12) is a cytokine that promotes cell-mediated immunity to intracellular pathogens by inducing type 1 helper T cell (TH1) responses and interferon-gamma (IFN-gamma) production. IL-12 binds to high-affinity beta1/beta2 heterodimeric IL-12 receptor (IL-12R) complexes on T cell and...

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Identifiers

PMID: 9603733
DOI: 10.1126/science.280.5368.1435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-9603733-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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