Article
Alternative splicing of the mouse amelogenin primary RNA transcript contributes to amelogenin heterogeneity.
Biochemical and biophysical research communications - 16 Nov 1992
Lau E C, Simmer J P, Bringas P, Hsu D D, Hu C C, Zeichner-David M, Thiemann F, Snead M L, Slavkin H C, Fincham A G
Abstract excerpt
A heterogeneous population of amelogenin proteins is derived from a single copy of the mouse amelogenin gene. To investigate the one gene--multiple protein enigma, we designed a study to distinguish between alternative splicing and proteolytic cleavage models. A pulse of [35S]methionine labeling demonstrated that multiple amelogenins are synthesized concurrently, a result consistent with an alternative splicing...
Topics
- Alternative Splicing
- Amelogenin
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- Dental Enamel Proteins
- Exons
- Genetic Variation
- Introns
- Isoelectric Point