Article
Primary Sjögren's syndrome: role of the HLA-DRB1*0301-*1501 heterozygotes.
The Journal of rheumatology - 1 May 1998
Guggenbuhl P, Jean S, Jego P, Grosbois B, Chalès G, Semana G, Lancien G, Veillard E, Pawlotsky Y, Perdriger A
Abstract excerpt
OBJECTIVE: To examine the respective role of the DRB1*, DQB1*, and DPB1* HLA alleles in primary Sjögren's syndrome (SS) and in the clinical and autoantibody profile of primary SS. METHODS: HLA-DRB1*, DQB1*, and DPB1* alleles were analyzed in 42 patients with primary SS and 200 controls by reverse dot blot hybridization for DRB1* and DPB1* and by polymerase chain reaction-restriction fragment length polymorphism...
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