DRB1*15 and DRB1*03 extended haplotype interaction in primary Sjögren's syndrome genetic susceptibility.

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Article

DRB115 and DRB103 extended haplotype interaction in primary Sjögren's syndrome genetic susceptibility.

Clinical and experimental rheumatology - 1 Jan 2000

Jean S, Quelvennec E, Alizadeh M, Guggenbuhl P, Birebent B, Perdriger A, Grosbois B, Pawlotsky P Y, Semana G

Abstract excerpt

OBJECTIVE: Sjögren's syndrome (SS) is a chronic autoimmune disease with a genetic component. Among the genetic factors, the role of HLA class II genes has been suggested and a positive association with DRB1*03 allele has been described. However, there is no consensus on a unique HLA locus for thi...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 3
ATP-Binding Cassette Transporters
Genes, MHC Class II
Genetic Predisposition to Disease
HLA-DR Antigens
HLA-DRB1 Chains
Haplotypes
Heterozygote
Humans
Microsatellite Repeats
Polymorphism, Genetic
Sjogren's Syndrome
Tumor Necrosis Factor-alpha

Source

Open in PubMed

Identifiers

PMID: 9844767

Genes

TAP1
TAP2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9844767-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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