Article
Specific HLA-DQA and HLA-DRB1 alleles confer susceptibility to Sjögren's syndrome and autoantibody production.
Journal of clinical laboratory analysis - 1 Jan 1991
Fei H M, Kang H, Scharf S, Erlich H, Peebles C, Fox R
Abstract excerpt
Primary Sjögren's syndrome (1. SS) is a systemic autoimmune disease characterized by lymphocytic infiltration of the salivary glands and autoantibody production. In order to identify genetic factors that play a role in pathogenesis and predict extent of disease, we used Southern blot and polymera...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Autoantibodies
- Base Sequence
- Child
- DNA
- Female
- Genes, MHC Class II
- HLA-DQ Antigens
- HLA-DR Antigens
- HLA-DRB1 Chains
- HLA-DRB3 Chains
- Histocompatibility Antigens Class II
- Humans
- Male
- Middle Aged