Article
In vitro activities of 13 fluoroquinolones against Staphylococcus aureus isolates with characterized mutations in gyrA, gyrB, grlA, and norA and against wild-type isolates.
Antimicrobial agents and chemotherapy - 1 Apr 1999
Muñoz Bellido J L, Alonso Manzanares M A, Yagüe Guirao G, Gutiérrez Zufiaurre M N, Toldos M C, Segovia Hernández M, Garcia-Rodríguez J A
Abstract excerpt
The in vitro activities of 13 fluoroquinolones (FQs) were tested against 90 Staphylococcus aureus clinical isolates: 30 wild type for gyrA, gyrB, grlA and norA and 60 with mutations in these genes. Clinafloxacin (CI-960), sparfloxacin, and grepafloxacin were the most active FQs against wild-type isolates (MICs at which 90% of isolates were inhibited, 0.06 to 0.1 microgram/ml). Mutations in grlA did not affect the...
Topics
- Anti-Infective Agents
- Bacterial Proteins
- DNA Gyrase
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- Fluoroquinolones
- Humans
- Microbial Sensitivity Tests
- Multidrug Resistance-Associated Proteins