Activation of the proto-oncogene c-myc and c-fos by c-ras: involvement of polyamines.

doi:10.1006/bbrc.1994.1990

Back to search

Article

Activation of the proto-oncogene c-myc and c-fos by c-ras: involvement of polyamines.

Biochemical and biophysical research communications - 29 Jul 1994

Tabib A, Bachrach U

Abstract excerpt

Rat kidney cells infected with a temperature-sensitive mutant of Kirsten sarcoma virus (Ki-MSV ts 371) expressed Ki-Ras at 37 degrees C but not at 42 degrees C. This expression of the oncogene was accompanied by an increase in the activity of ornithine decarboxylase (ODC) and the accumulation of...

Topics

Animals
Blotting, Northern
Blotting, Western
Cell Line, Transformed
Gene Expression
Genes, fos
Genes, myc
Genes, ras
Kidney
Kirsten murine sarcoma virus
Mutation
Ornithine Decarboxylase
Putrescine
Rats
Signal Transduction
Temperature
Transcription, Genetic

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.