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Article

5-HT1B receptor polymorphism and clinical response to sumatriptan.

Headache - 1 Apr 1998

MaassenVanDenBrink A, Vergouwe M N, Ophoff R A, Saxena P R, Ferrari M D, Frants R R

Abstract excerpt

The 5-HT1 receptor agonist, sumatriptan, is highly effective in the treatment of migraine. Some patients, however, do not respond or experience recurrence of the headache. In addition, some patients report chest symptoms after sumatriptan. We investigated whether these different responses could be attributed to genetic diversity of the 5-HT1B receptor, which most likely mediates the therapeutic action and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9595868
DOI: 10.1046/j.1526-4610.1998.3804288.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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5-HT1B receptor polymorphism and clinical response to sumatriptan.PMID 9595868Read ↗

The phe-124-Cys and A-161T variants of the human 5-HT1B receptor gene are not major determinants of the clinical response to sumatriptan.Semantic proximity Read ↗

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5-Hydroxytryptamine-induced contraction of human temporal arteries coexpressing 5-HT2A receptors and wild-type or variant (Phe124Cys) 5-HT1B receptors: increased contribution of 5-HT1B receptors to the total contractile amplitude in arteries from Phe124Cys heterozygous individuals.Semantic proximity Read ↗

No association of C-1019G promoter polymorphism of 5-HT1A receptor gene with migraine.Semantic proximity Read ↗

The G1246A polymorphism in the hypocretin receptor 2 gene is not associated with treatment response in cluster headache.Semantic proximity Read ↗

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