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Article

The G1246A polymorphism in the hypocretin receptor 2 gene is not associated with treatment response in cluster headache.

Cephalalgia : an international journal of headache - 1 Apr 2007

Schürks M, Kurth T, Geissler I, Tessmann G, Diener H-C, Rosskopf D

Abstract excerpt

The risk of cluster headache (CH) is associated with the G-allele of the G1246A polymorphism in the hypocretin receptor 2 (HCRTR2) gene. First-line medication is effective in only about 70-80% of CH patients. We hypothesized that the HCRTR2 G1246A polymorphism is also of pharmacogenetic relevance in CH and may affect treatment response. We performed a prospective cohort study among 184 unrelated White CH...

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Source

Identifiers

PMID: 17376114
DOI: 10.1111/j.1468-2982.2007.01287.x

Genes

HCRTR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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