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Article

Protein Kinase C recognition sites in the cytoplasmic domain of Endothelin Converting Enzyme-1c.

Biochemical and biophysical research communications - 26 Oct 2012

Kuruppu Sanjaya, Tochon-Danguy Nathalie, Smith A Ian

Abstract excerpt

Endothelin Converting Enzyme-1 (ECE-1) is essential for the production of the potent vasoconstrictor Endothelin-1 (ET-1). The activation of Protein Kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) can increase ECE-1 phosphorylation, which in turn promotes ECE-1c trafficking to the cell surface where ET-1 production occurs. This study has identified the specific residues in the N-terminal cytoplasmic tail...

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Identifiers

PMID: 23022525
DOI: 10.1016/j.bbrc.2012.09.105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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