Article
Evaluation of the role of Finnish ataxia-telangiectasia mutations in hereditary predisposition to breast cancer.
Carcinogenesis - 1 May 2007
Pylkäs Katri, Tommiska Johanna, Syrjäkoski Kirsi, Kere Juha, Gatei Magtouf, Waddell Nicola, Allinen Minna, Karppinen Sanna-Maria, Rapakko Katrin, Kääriäinen Helena, Aittomäki Kristiina, Blomqvist Carl, Mustonen Aki, Holli Kaija, Khanna Kum Kum, Kallioniemi Olli-Pekka, Nevanlinna Heli, Winqvist Robert
Abstract excerpt
Biallelic mutations in the ataxia-telangiectasia mutated (ATM) gene result in ataxia-telangiectasia (A-T). Studies on A-T families have shown that obligate female carriers have increased risk of developing breast cancer. Here we have evaluated the role of known Finnish ATM germ line mutations as possible breast cancer predisposing alleles outside A-T families by analyzing their prevalence in large cohorts of...
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