Article
Evaluation of the role of Finnish ataxia-telangiectasia mutations in hereditary predisposition to breast cancer.
Carcinogenesis - 1 May 2007
Pylkäs Katri, Tommiska Johanna, Syrjäkoski Kirsi, Kere Juha, Gatei Magtouf, Waddell Nicola, Allinen Minna, Karppinen Sanna-Maria, Rapakko Katrin, Kääriäinen Helena, Aittomäki Kristiina, Blomqvist Carl, Mustonen Aki, Holli Kaija, Khanna Kum Kum, Kallioniemi Olli-Pekka, Nevanlinna Heli, Winqvist Robert
Abstract excerpt
Biallelic mutations in the ataxia-telangiectasia mutated (ATM) gene result in ataxia-telangiectasia (A-T). Studies on A-T families have shown that obligate female carriers have increased risk of developing breast cancer. Here we have evaluated the role of known Finnish ATM germ line mutations as...
Topics
- Ataxia Telangiectasia
- Ataxia Telangiectasia Mutated Proteins
- Breast Neoplasms
- Cell Cycle Proteins
- Cohort Studies
- DNA-Binding Proteins
- Female
- Finland
- Genetic Predisposition to Disease
- Humans
- Male
- Mutation
- Pedigree