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Article

A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screening.

JAMA - 15 Feb 1995

Shattuck-Eidens D, McClure M, Simard J, Labrie F, Narod S, Couch F, Hoskins K, Weber B, Castilla L, Erdos M

Abstract excerpt

OBJECTIVES: To report the initial experience of an international group of investigators in identifying mutations in the BRCA1 breast and ovarian cancer susceptibility gene, to assess the spectrum of such mutations in samples from patients with different family histories of cancer, and to determin...

Topics

Adult
BRCA1 Protein
Breast Neoplasms
DNA Mutational Analysis
Female
Genetic Testing
Humans
Middle Aged
Mutation
Neoplasm Proteins
Ovarian Neoplasms
Sensitivity and Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription Factors

Source

Identifiers

PMID: 7837387

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7837387-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screening.PMID 7837387Read ↗

A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screeningSemantic proximity Read ↗

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High proportion of recurrent germline mutations in the BRCA1 gene in breast and ovarian cancer patients from the Prague areaSemantic proximity Read ↗

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Germline BRCA1 alterations in a population-based series of ovarian cancer cases.Semantic proximity Read ↗

Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype-phenotype correlation.Semantic proximity Read ↗

BRCA1 sequence analysis in women at high risk for susceptibility mutations. Risk factor analysis and implications for genetic testing.Semantic proximity Read ↗

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