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Article

The (6-4) photoproduct of thymine-thymine induces targeted substitution mutations in mammalian cells.

Nucleic acids research - 1 Jun 1998

Kamiya H, Iwai S, Kasai H

Abstract excerpt

Two major ultraviolet-induced photolesions of TpT, a (6-4) photoproduct [T(6-4)T] and a cis-syn cyclobutane TT dimer (T=T), were incorporated into a predetermined site of one of the leading and lagging template strands of a double-stranded vector, and the modified DNAs were transfected into simian COS-7 cells. The DNAs replicated in the cells were recovered and were transfected again into Escherichia coli. The...

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Identifiers

PMID: 9592145
DOI: 10.1093/nar/26.11.2611
PMCID: PMC147589

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