Article
Constitutively active Gs alpha is associated with an increased phosphodiesterase activity in human growth hormone-secreting adenomas.
The Journal of clinical endocrinology and metabolism - 1 May 1998
Lania A, Persani L, Ballaré E, Mantovani S, Losa M, Spada A
Abstract excerpt
Because phosphodiesterase (PDE) expression and activity are controlled by cAMP, we investigated whether activating mutations of Gs alpha gene that occur in human GH-secreting adenomas are associated with increased PDE activity. We studied 10 adenomas with wild-type Gs alpha (gsp-) and 8 with muta...
Topics
- 1-Methyl-3-isobutylxanthine
- Adenoma
- Adult
- Aged
- Enzyme Inhibitors
- Female
- GTP-Binding Protein alpha Subunits, Gs
- Glycoproteins
- Human Growth Hormone
- Humans
- Male
- Middle Aged
- Mutation
- Pituitary Neoplasms
- Tumor Cells, Cultured