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Article

Phosphodiesterases and cAMP Pathway in Pituitary Diseases

19 Mar 2019

Abstract excerpt

Human phosphodiesterases (PDEs) comprise a complex superfamily of enzymes derived from 24 genes separated into 11 PDE gene families (PDEs 1-11), expressed in different tissues and cells, including heart and brain. The isoforms PDE 4, 7 and 8 are specific for the second messenger cAMP, which is responsible for mediating diverse physiological actions involving different hormones and neurotransmitters. The cAMP...

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Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
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PMID: 30941100
DOI: 10.3389/fendo.2019.00141

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