Article
High frequency of CYP1A1 mutations in a Turkish population.
Archives of toxicology - 1 Mar 1998
Aynacioglu A S, Cascorbi I, Mrozikiewicz P M, Roots I
Abstract excerpt
The frequency distribution of four cytochrome P4501A1 (CYP1A1) gene mutations was investigated in 271 Turks from southeast Anatolia by polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) assay. Allelic linkage of those mutations was proven by peptide nucleic acid-mediated PCR clamping. Mutation ml (T6235C) forming an MspI restriction site in the 3'-flanking region occurred with 18.1%...
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