Adenomatous Polyposis Coli Gene Polyposis-Related Syndromes.

Abstract excerpt

Gastrointestinal cancers, particularly those of the stomach and colorectum, are among the leading causes of cancer-related morbidity and mortality in the United States and worldwide. The adenomatous polyposis coli ( APC ) gene functions as a tumor suppressor gene whose loss of function plays a critical role in gastrointestinal cancer development. Pathogenic/likely pathogenic variants of the APC gene are...

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