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Article

Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy.

Nature neuroscience - 1 Sept 2006

Yu Frank H, Mantegazza Massimo, Westenbroek Ruth E, Robbins Carol A, Kalume Franck, Burton Kimberly A, Spain William J, McKnight G Stanley, Scheuer Todd, Catterall William A

Abstract excerpt

Voltage-gated sodium channels (Na(V)) are critical for initiation of action potentials. Heterozygous loss-of-function mutations in Na(V)1.1 channels cause severe myoclonic epilepsy in infancy (SMEI). Homozygous null Scn1a-/- mice developed ataxia and died on postnatal day (P) 15 but could be sustained to P17.5 with manual feeding. Heterozygous Scn1a+/- mice had spontaneous seizures and sporadic deaths beginning...

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Source

Identifiers

PMID: 16921370
DOI: 10.1038/nn1754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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