Trinucleotide repeats (CGG)22TGG(CGG)43TGG(CGG)21 from the fragile X gene remain stable in transgenic mice.

doi:10.1007/s004390050525

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Article

Trinucleotide repeats (CGG)22TGG(CGG)43TGG(CGG)21 from the fragile X gene remain stable in transgenic mice.

Human genetics - 1 Sept 1997

Lavedan C N, Garrett L, Nussbaum R L

Abstract excerpt

Unstable premutation alleles in fragile X contain CGG repeats ranging from 34 to about 200. To study the mechanism of formation and the behavior of dynamic mutations, we constructed and cloned 88 trinucleotide repeats including 43 uninterrupted CGGs and injected them into mouse fertilized oocytes...

Topics

Animals
Cloning, Molecular
Female
Fragile X Syndrome
Germ-Line Mutation
Humans
Male
Mice
Mice, Transgenic
Mutation
Pedigree
Trinucleotide Repeats

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