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Article

Hypermutable myotonic dystrophy CTG repeats in transgenic mice.

Nature genetics - 1 Feb 1997

Monckton D G, Coolbaugh M I, Ashizawa K T, Siciliano M J, Caskey C T

Abstract excerpt

Myotonic dystrophy (DM) is one of a growing number of inherited human disorders associated with the expansion of triplet repeat DNA sequences. Expanded alleles are highly unstable in both the germline and soma, accounting in large part for the unusual genetics of this disorder, its phenotypic variability and probably, the progressive nature of the symptoms. However, the molecular mechanisms and the genetic...

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PMID: 9020848
DOI: 10.1038/ng0297-193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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