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Article

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.

Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 1996

Cook D G, Sung J C, Golde T E, Felsenstein K M, Wojczyk B S, Tanzi R E, Trojanowski J Q, Lee V M, Doms R W

Abstract excerpt

Mutations in the recently identified presenilin 1 gene on chromosome 14 cause early onset familial Alzheimer disease (FAD). Herein we describe the expression and analysis of the protein coded by presenilin 1 (PS1) in NT2N neurons, a human neuronal model system. PS1 was expressed using recombinant...

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Identifiers

PMID: 8799182
DOI: 10.1073/pnas.93.17.9223
PMCID: PMC38623

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-8799182-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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