Heavy Chain Ferritin Enhances Serine Hydroxymethyltransferase Expression and de Novo Thymidine Biosynthesis

Abstract excerpt

We have elucidated a biochemical mechanism whereby changes in iron metabolism cause changes in folate-dependent one-carbon metabolism. Although animal and clinical studies have demonstrated that perturbations in iron status and metabolism alter folate metabolism, the biochemical mechanisms underlying these associations have yet to be identified. The effect of altered ferritin expression on folate metabolism was...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Folate and B Vitamins Research
• Share to Hemoglobinopathies and Related Disorders
• Share to Iron Metabolism and Disorders