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Article

Human Mitochondrial C1-Tetrahydrofolate Synthase

1 Oct 2003

Abstract excerpt

C1-tetrahydrofolate (THF) synthase is a trifunctional enzyme found in eukaryotes that contains the activities 10-formyl-THF synthetase, 5,10-methenyl-THF cyclohydrolase, and 5,10-methylene-THF dehydrogenase. The cytoplasmic isozyme of C1-THF synthase is well characterized in a number of mammals, including humans; but a mitochondrial isozyme has been previously identified only in the yeast Saccharomyces. Here, we...

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Identifiers

PMID: 12937168
DOI: 10.1074/jbc.m304319200

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