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Article

Mutations in the leucine zipper-like heptad repeat sequence of human immunodeficiency virus type 1 gp41 dominantly interfere with wild-type virus infectivity.

Journal of virology - 1 Jun 1998

Chen S S, Lee S F, Hao H J, Chuang C K

Abstract excerpt

It has been previously shown that a proline substitution for any of the conserved leucine or isoleucine residues located in the leucine zipper-like heptad repeat sequence of human immunodeficiency virus type 1 (HIV-1) gp41 renders viruses noninfectious and envelope (Env) protein unable to mediate membrane fusion (S. S.-L. Chen, C.-N. Lee, W.-R. Lee, K. McIntosh, and T.-M. Lee, J. Virol. 67:3615-3619, 1993; S....

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Identifiers

PMID: 9573241
DOI: 10.1128/JVI.72.6.4765-4774.1998
PMCID: PMC110011

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