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Article

Mutations in the leucine zipper-like heptad repeat sequence of human immunodeficiency virus type 1 gp41 dominantly interfere with wild-type virus infectivity.

Journal of virology - 1 Jun 1998

Chen S S, Lee S F, Hao H J, Chuang C K

Abstract excerpt

It has been previously shown that a proline substitution for any of the conserved leucine or isoleucine residues located in the leucine zipper-like heptad repeat sequence of human immunodeficiency virus type 1 (HIV-1) gp41 renders viruses noninfectious and envelope (Env) protein unable to mediate...

Topics

Amino Acid Sequence
HIV Envelope Protein gp41
HIV Infections
HIV-1
HeLa Cells
Humans
Leucine Zippers
Molecular Sequence Data
Mutation
Repetitive Sequences, Nucleic Acid
Transfection
Virulence

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Virus Replication

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Identifiers

PMID: 9573241
DOI: 10.1128/JVI.72.6.4765-4774.1998
PMCID: PMC110011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9573241-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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