Article
Basic FGF, EGF, and PDGF modify TGFbeta-induction of smooth muscle cell phenotype in human prostatic stromal cells.
The Prostate - 1 May 1998
Peehl D M, Sellers R G
Abstract excerpt
BACKGROUND: We investigated the ability of a variety of growth factors to regulate the differentiation of prostatic fibroblasts into smooth muscle cells. METHODS: Smooth muscle actin levels were monitored by immunoblot analysis and immunocytochemistry. Proliferation was measured in clonal growth assays and by cell counts. RESULTS: We determined that TGFbeta inhibited proliferation and induced smooth muscle...
Topics
- Actins
- Adenocarcinoma
- Epidermal Growth Factor
- Fibroblast Growth Factor 2
- Humans
- Immunohistochemistry
- Male
- Muscle, Smooth
- Phenotype
- Platelet-Derived Growth Factor
- Prostatic Neoplasms