Article
TGFbeta-1 and epithelial-mesenchymal interactions promote smooth muscle gene expression in bone marrow stromal cells: possible application in therapies for urological defects.
The International journal of artificial organs - 1 Nov 2008
Becker C, Laeufer T, Arikkat J, Jakse G
Abstract excerpt
PURPOSE: For regenerative and cellular therapies of the urinary tract system, autologous bladder smooth muscle cells (SMCs) have several limitations, including constricted in vitro proliferation capacity and, more importantly, inability to be used in malignant conditions. The use of in vitro (pre-)differentiated multipotential adult progenitor cells may help to overcome the shortcomings associated with primary...
Topics
- Actins
- Animals
- Bone Marrow Cells
- Cell Adhesion
- Cell Communication
- Cell Differentiation
- Cell Lineage
- Cells, Cultured
- Coculture Techniques
- Desmin
- Epithelial Cells