CD8+ EFFECTOR CELLS RESPONDING TO RESIDUAL CLASS I ANTIGENS, WITH HELP FROM CD4+ CELLS STIMULATED INDIRECTLY, CAUSE REJECTION OF ???MAJOR HISTOCOMPATIBILITY COMPLEX-DEFICIENT??? SKIN GRAFTS1

Abstract excerpt

BACKGROUND: Skin grafts from mice that are deficient in the expression of both class I and class II major histocompatibility complex (MHC) antigens are rejected rapidly by normal recipients. METHODS: To determine the mechanism of this rejection, MHC-deficient skin grafts were placed on recipients with different degrees of antigenic disparity and on recipients depleted of selected T cell subpopulations. In...

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