Article
Dual sorting of the Saccharomyces cerevisiae vacuolar protein Sna4p.
Eukaryotic cell - 1 Mar 2009
Pokrzywa W, Guerriat B, Dodzian J, Morsomme P
Abstract excerpt
Sna4p, a vacuolar membrane protein, belongs to a small family of proteins conserved in plants and fungi. It is transported to the vacuolar membrane via the alkaline phosphatase (ALP) pathway, which bypasses the multivesicular bodies (MVBs). Here, we show that transfer of Sna4p by the ALP route involves the AP-3 adaptor protein complex, which binds to an acidic dileucine sorting signal in the cytoplasmic region of...
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