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Article

The yeast adaptor protein complex, AP-3, is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole.

The Journal of cell biology - 29 Dec 1997

Stepp J D, Huang K, Lemmon S K

Abstract excerpt

A novel clathrin adaptor-like complex, adaptor protein (AP)-3, has recently been described in yeast and in animals. To gain insight into the role of yeast AP-3, a genetic strategy was devised to isolate gene products that are required in the absence of the AP-3 mu chain encoded by APM3. One gene identified by this synthetic lethal screen was VPS45. The Vps pathway defines the route that several proteins,...

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Identifiers

PMID: 9412470
DOI: 10.1083/jcb.139.7.1761
PMCID: PMC2132655

Genes

VPS45

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