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Article

The yeast adaptor protein complex, AP-3, is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole.

The Journal of cell biology - 29 Dec 1997

Stepp J D, Huang K, Lemmon S K

Abstract excerpt

A novel clathrin adaptor-like complex, adaptor protein (AP)-3, has recently been described in yeast and in animals. To gain insight into the role of yeast AP-3, a genetic strategy was devised to isolate gene products that are required in the absence of the AP-3 mu chain encoded by APM3. One gene...

Topics

Alkaline Phosphatase
Biological Transport
Fungal Proteins
Gene Deletion
Membrane Proteins
Models, Biological
Nuclear Proteins
Phenotype
Protein Processing, Post-Translational
RNA-Binding Proteins
Saccharomyces cerevisiae Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vacuoles

Vesicular Transport Proteins

Yeasts

Source

Open in PubMed Open full text

Identifiers

PMID: 9412470
DOI: 10.1083/jcb.139.7.1761
PMCID: PMC2132655

Genes

VPS45

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9412470-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The yeast adaptor protein complex, AP-3, is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole.PMID 9412470Read ↗

Vps41p function in the alkaline phosphatase pathway requires homo-oligomerization and interaction with AP-3 through two distinct domains.Semantic proximity Read ↗

A dileucine-like sorting signal directs transport into an AP-3-dependent, clathrin-independent pathway to the yeast vacuole.Semantic proximity Read ↗

Genetically encoded multimode reporter of adaptor protein 3 (AP-3) traffic in budding yeastSemantic proximity Read ↗

Acidic di-leucine motif essential for AP-3-dependent sorting and restriction of the functional specificity of the Vam3p vacuolar t-SNARE.Semantic proximity Read ↗

A novel mechanism for localizing membrane proteins to yeast trans-Golgi network requires function of synaptojanin-like protein.Semantic proximity Read ↗

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A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole.Semantic proximity Read ↗

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A late Golgi sorting function for Saccharomyces cerevisiae Apm1p, but not for Apm2p, a second yeast clathrin AP medium chain-related protein.Semantic proximity Read ↗

Avl9p, a member of a novel protein superfamily, functions in the late secretory pathway.Semantic proximity Read ↗

Identification of Cargo for Adaptor Protein (AP) Complexes 3 and 4 by Sucrose Gradient Profiling.Semantic proximity Read ↗

A yeast lysosomal biogenesis map uncovers the cargo spectrum of lysosomal protein targeting pathwaysSemantic proximity Read ↗

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