Article
Mutations in aarE, the ubiA homolog of Providencia stuartii, result in high-level aminoglycoside resistance and reduced expression of the chromosomal aminoglycoside 2'-N-acetyltransferase.
Antimicrobial agents and chemotherapy - 1 Apr 1998
Paradise M R, Cook G, Poole R K, Rather P N
Abstract excerpt
The aarE1 allele was identified on the basis of the resulting phenotype of increased aminoglycoside resistance. The aarE1 mutation also resulted in a small-colony phenotype and decreased levels of aac(2')-Ia mRNA. The deduced AarE gene product displayed 61% amino acid identity to the Escherichia...
Topics
- Acetyltransferases
- Alkyl and Aryl Transferases
- Alleles
- Aminoglycosides
- Anti-Bacterial Agents
- Blotting, Northern
- Chromosomes, Bacterial
- DNA, Bacterial
- Molecular Sequence Data
- Plasmids
- Providencia