Article
A regulatory cascade involving AarG, a putative sensor kinase, controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii.
Molecular microbiology - 1 Jun 1998
Rather P N, Paradise M R, Parojcic M M, Patel S
Abstract excerpt
A recessive mutation, aarG1, has been identified that resulted in an 18-fold increase in the expression of beta-galactosidase from an aac(2')-lacZ fusion. Transcriptional fusions and Northern blot analysis demonstrated that the aarG1 allele also resulted in a large increase in the expression of a...
Topics
- Acetyltransferases
- Alleles
- Anti-Bacterial Agents
- Bacterial Proteins
- Blotting, Northern
- DNA-Binding Proteins
- Drug Resistance, Microbial
- Drug Resistance, Multiple
- Escherichia coli Proteins
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Microbial Sensitivity Tests
- Molecular Sequence Data