Article
A49T, V89L and TA repeat polymorphisms of steroid 5alpha-reductase type II and breast cancer risk in Japanese women.
Breast cancer research : BCR - 1 Jan 2002
Yang Chunxia, Hamajima Nobuyuki, Iwata Hiroji, Saito Toshiko, Matsuo Keitaro, Hirose Kaoru, Inoue Manami, Takezaki Toshiro, Tajima Kazuo
Abstract excerpt
BACKGROUND: Breast cancer is hormone related, as are cancers of the endometrium, ovary, and prostate. Several studies have suggested that higher extracellular levels of androgens are associated with breast cancer risk, while biological evidence indicates that androgens are protective. The codon 49 alanine to threonine substitution (A49T), codon 89 valine to leucine substitution (V89L) and TA repeat polymorphisms...
Topics
Join the communities discussing this publication.