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Capsid Is a Dominant Determinant of Retrovirus Infectivity in Nondividing Cells

12 May 2004

Abstract excerpt

A major difference between lentiviruses such as human immunodeficiency virus (HIV) and most other retroviruses is their ability to productively infect nondividing cells. We present here genetic evidence for involvement of the capsid protein (CA) in the infectious phenotype in nondividing cells. A chimeric HIV type 1 (HIV-1) in which the MA and CA of HIV-1 are replaced with the MA, p12, and CA encoding sequences...

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PMID: 15140964
DOI: 10.1128/jvi.78.11.5670-5678.2004

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