Article
Lack of association between the angiotensin-converting enzyme insertion/deletion polymorphism and plasminogen activator inhibitor-1 antigen levels in the National Heart, Lung, and Blood Institute Family Heart Study.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Sept 2000
Pankow J S, Arnett D K, Borecki I B, Hunt S C, Eckfeldt J H, Folsom A R, Djoussé L
Abstract excerpt
Experimental and clinical research supports a direct link between activation of the renin-angiotensin system and production of plasminogen activator inhibitor-1 (PAI-1), the primary physiologic inhibitor of tissue plasminogen activator. Several studies have reported higher PAI-1 levels in individuals carrying the deletion (D) allele of the angiotensin-converting enzyme (ACE) gene. We investigated the association...
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