Article
Modeling disease incidence rates in families.
Epidemiology (Cambridge, Mass.) - 1 Sept 1998
Siegmund K D, Province M A, Higgins M, Williams R R, Keller J, Todorov A A
Abstract excerpt
We apply an extended Cox model to study latent genes and measured environmental exposures simultaneously as risk factors for disease. Using this method, we assume Mendelian transmission of the genes and either dominant or recessive gene action. We compared the results from this model with those obtained under a model that includes the environmental variables and a family risk score. We demonstrate the method in...
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