Improved tests for heterogeneity across a region of DNA sequence in the ratio of polymorphism to divergence.

doi:10.1093/oxfordjournals.molbev.a025934

Back to search

Article

Improved tests for heterogeneity across a region of DNA sequence in the ratio of polymorphism to divergence.

Molecular biology and evolution - 1 Apr 1998

McDonald J H

Abstract excerpt

The neutral theory of molecular evolution predicts that the ratio of polymorphisms to fixed differences should be fairly uniform across a region of DNA sequence. Significant heterogeneity in this ratio can indicate the effects of balancing selection, selective sweeps, mildly deleterious mutations...

Topics

Animals
Biometry
DNA
Drosophila melanogaster
Evolution, Molecular
Genes, Insect
Genetic Variation
Models, Genetic
Polymorphism, Genetic
Selection, Genetic

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.