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Article

Lack of translation of normal 7B2 mRNA levels in hypothalamic mutant vasopressin cells of the homozygous Brattleboro rat.

Neuroscience letters - 12 Dec 1997

Gabreëls B A, Verwer R W, Sonnemans M A, Sluiter A A, Ang C W, van Leeuwen F W

Abstract excerpt

The homozygous Brattleboro rat (di/di) synthesizes a vasopressin (VP) precursor with an aberrant C-terminus, which causes a hypothalamic form of diabetes insipidus. The neuroendocrine polypeptide 7B2 is present in VP and oxytocin (OT) neurons of the supraoptic and paraventricular nucleus of the hypothalamus in wild type rats. However, in the di/di rat 7B2 immunoreactivity is absent in the VP cell population,...

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PMID: 9547170
DOI: 10.1016/s0304-3940(97)00883-5

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Lack of translation of normal 7B2 mRNA levels in hypothalamic mutant vasopressin cells of the homozygous Brattleboro rat.PMID 9547170Read ↗

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