Article
Lack of translation of normal 7B2 mRNA levels in hypothalamic mutant vasopressin cells of the homozygous Brattleboro rat.
Neuroscience letters - 12 Dec 1997
Gabreëls B A, Verwer R W, Sonnemans M A, Sluiter A A, Ang C W, van Leeuwen F W
Abstract excerpt
The homozygous Brattleboro rat (di/di) synthesizes a vasopressin (VP) precursor with an aberrant C-terminus, which causes a hypothalamic form of diabetes insipidus. The neuroendocrine polypeptide 7B2 is present in VP and oxytocin (OT) neurons of the supraoptic and paraventricular nucleus of the h...
Topics
- Animals
- Female
- Homozygote
- Hypothalamus
- In Situ Hybridization
- Male
- Mutation
- Nerve Tissue Proteins
- Neuroendocrine Secretory Protein 7B2
- Neurons
- Neurosecretory Systems
- Pituitary Hormones
- Protein Biosynthesis
- RNA, Messenger
- Rats
- Rats, Brattleboro
- Reference Values
- Vasopressins