Article
Mutant vasopressin precursor producing cells of the homozygous Brattleboro rat as a model for co-expression of neuropeptides.
Progress in brain research - 1 Jan 1992
van Leeuwen F W
Abstract excerpt
The homozygous Brattleboro rat (di/di) synthesizes a VP precursor with an abnormal C terminus, which is not transported from the rough endoplasmic reticulum to the Golgi apparatus. In addition, the phenotypic expression of co-existing peptides is differentially disturbed. Ang II and 7B2 are two of the peptides which are not detectable, whereas other peptides (e.g. galanin) are clearly expressed in mutant VP...
Topics
- Animals
- Endoplasmic Reticulum
- Exons
- Gene Expression
- Homozygote
- Hypothalamus
- Lysosomes
- Mutation
- Neurons
- Neuropeptides
- Paraventricular Hypothalamic Nucleus
- Protein Precursors