A murine model of autosomal dominant neurohypophyseal diabetes insipidus reveals progressive loss of vasopressin-producing neurons.

Abstract excerpt

Familial neurohypophyseal diabetes insipidus (FNDI) is an autosomal dominant disorder caused by mutations in the arginine vasopressin (AVP) precursor. The pathogenesis of FNDI is proposed to involve mutant protein-induced loss of AVP-producing neurons. We established murine knock-in models of two different naturally occurring human mutations that cause FNDI. A mutation in the AVP signal sequence [A(-1)T] is...

Topics

• Animals
• Apoptosis
• Arginine Vasopressin
• Diabetes Insipidus, Neurogenic
• Disease Models, Animal
• Drinking
• Hypothalamus
• Immunohistochemistry
• Mice
• Mutation
• Neurons