Article
Immunocytochemical evidence for the presence of vasopressin in intermediate sized neurosecretory granules of solitary neurohypophyseal terminals in the homozygous Brattleboro rat.
Neuroscience - 1 May 1996
Sonnemans M S, Evans D A, Burbach J P, Van Leeuwen F W
Abstract excerpt
A single base deletion (delta G) in the vasopressin gene is the cause of diabetes insipidus in the homozygous Brattleboro rat (di/di). The resulting frameshift leads to the expression of an aberrant vasopressin precursor which is unable to enter the secretory pathway, thereby preventing vasopress...
Topics
- Animals
- Base Sequence
- Cytoplasmic Granules
- Female
- Immunohistochemistry
- Male
- Microscopy, Electron
- Microscopy, Immunoelectron
- Molecular Sequence Data
- Mutation
- Neurosecretory Systems
- Pituitary Gland, Posterior
- Presynaptic Terminals
- Rats
- Rats, Brattleboro
- Solitary Nucleus
- Vasopressins