Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reproduction of human fibrous dysplasia of bone in immunocompromised mice by transplanted mosaics of normal and Gsalpha-mutated skeletal progenitor cells.

The Journal of clinical investigation - 15 Apr 1998

Bianco P, Kuznetsov S A, Riminucci M, Fisher L W, Spiegel A M, Robey P G

Abstract excerpt

We have isolated progenitor cells from the stromal system of the fibrous dysplastic marrow of patients with McCune-Albright Syndrome. Analysis of the Gsalpha gene from individual colonies provided direct evidence for the presence of two different genotypes within single fibrous dysplastic lesions: marrow stromal cells containing two normal Gsalpha alleles, and those containing one normal allele and an allele with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Primers

Share to Mosaicism

Share to Mutation

Share to Polymerase Chain Reaction

Share to Transplantation, Heterologous

Source

Open in PubMed Open full text

Identifiers

PMID: 9541505
DOI: 10.1172/JCI2361
PMCID: PMC508756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reproduction of human fibrous dysplasia of bone in immunocompromised mice by transplanted mosaics of normal and Gsalpha-mutated skeletal progenitor cells.PMID 9541505Read ↗

G(s)alpha mutations in fibrous dysplasia and McCune-Albright syndrome.Semantic proximity Read ↗

Osteoblast-Specific Expression of the Fibrous Dysplasia (FD)–Causing Mutation <i>GsαR201C</i> Produces a High Bone Mass Phenotype but Does Not Reproduce FD in the MouseSemantic proximity Read ↗

Fibrous dysplasia/McCune-Albright syndrome: state-of-the-art advances, pathogenesis, and basic/translational researchSemantic proximity Read ↗

Etiology of fibrous dysplasia and McCune-Albright syndrome.Semantic proximity Read ↗

Mutations of the GNAS1 gene, stromal cell dysfunction, and osteomalacic changes in non-McCune-Albright fibrous dysplasia of bone.Semantic proximity Read ↗

An unusual presentation of McCune-Albright syndrome confirmed by an activating mutation of the Gs alpha-subunit from a bone lesion.Semantic proximity Read ↗

The histopathology of fibrous dysplasia of bone in patients with activating mutations of the Gs alpha gene: site-specific patterns and recurrent histological hallmarks.Semantic proximity Read ↗

GNAS transcripts in skeletal progenitors: evidence for random asymmetric allelic expression of Gs alpha.Semantic proximity Read ↗

Age-dependent demise of GNAS-mutated skeletal stem cells and "normalization" of fibrous dysplasia of bone.Semantic proximity Read ↗

Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells.Semantic proximity Read ↗

An activating Gs alpha mutation is present in fibrous dysplasia of bone in the McCune-Albright syndromeSemantic proximity Read ↗

Hair follicle-resident progenitor cells are a major cellular contributor to heterotopic subcutaneous ossifications in a mouse model of Albright hereditary osteodystrophySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.