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Article

Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells.

Journal of molecular endocrinology - 1 Dec 2010

Riminucci Mara, Robey Pamela Gehron, Saggio Isabella, Bianco Paolo

Abstract excerpt

Activating mutations of the GNAS gene, which causes fibrous dysplasia of bone (FD), lead to remarkable changes in the properties of skeletal progenitors, and it is these changes that mediate the pathological effect of this gene on bone. Mutated skeletal stem cells lose the ability to differentiate into adipocytes, and to maintain in situ, and transfer heterotopically, the hematopoietic microenvironment, leading...

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Source

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Identifiers

PMID: 20841428
DOI: 10.1677/JME-10-0097
PMCID: PMC3384548

Genes

GNAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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