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Article

Age-dependent demise of GNAS-mutated skeletal stem cells and "normalization" of fibrous dysplasia of bone.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2008

Kuznetsov Sergei A, Cherman Natasha, Riminucci Mara, Collins Michael T, Robey Pamela Gehron, Bianco Paolo

Abstract excerpt

We studied the role of somatic mosaicism in fibrous dysplasia of bone (FD) within the context of skeletal ("mesenchymal") stem cells by assessing the frequency of mutated colony forming unit-fibroblasts (CFU-Fs) from FD lesions, and in some cases, from unaffected sites, in a series of patients. There was a tight inverse correlation between the percentage mutant CFU-F versus age, suggesting demise of mutant stem...

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Source

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Identifiers

PMID: 18597624
DOI: 10.1359/jbmr.080609
PMCID: PMC2585500

Genes

GNAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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