Effects of the apolipoprotein E polymorphism on uptake and transfer of cell-derived cholesterol in plasma.

doi:10.1172/JCI118336

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Article

Effects of the apolipoprotein E polymorphism on uptake and transfer of cell-derived cholesterol in plasma.

The Journal of clinical investigation - 1 Dec 1995

Huang Y, von Eckardstein A, Wu S, Assmann G

Abstract excerpt

The reverse cholesterol transport is initiated by the uptake of cholesterol into minor subfractions of high density lipoproteins (HDL) which contain either apolipoprotein (apo) A-I or apoE as their only apolipoproteins. From these initial acceptors, which are termed prebeta1-LpA-I and gamma-LpE, respectively, cell-derived cholesterol is transferred to LDL via the bulk of HDL termed alpha-LpA-I. In this study we...

Topics

Apolipoprotein A-I
Apolipoproteins
Apolipoproteins E
Cells, Cultured
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Electrophoresis, Gel, Two-Dimensional
Electrophoresis, Polyacrylamide Gel
Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Phenotype

Polymorphism, Genetic

Skin

Sphingomyelin Phosphodiesterase

Triglycerides

Type C Phospholipases

Source

Open in PubMed Open full text

Identifiers

PMID: 8675636
DOI: 10.1172/JCI118336
PMCID: PMC185976

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