Article
Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy.
Nature medicine - 1 Oct 1995
Bergh J, Norberg T, Sjögren S, Lindgren A, Holmberg L
Abstract excerpt
The complete coding region of the p53 gene was sequenced from 316 consecutively presented breast cancers, of which 97 were lymph node positive and 206 were node negative. The p53 status was related to prognosis and effect of adjuvant therapy. In all, 69 individual mutations, 29 in node-positive tumours, were demonstrated throughout the whole coding sequence. The mutation sites were partly different for...
Topics
- Amino Acids
- Antineoplastic Agents
- Breast Neoplasms
- Chemotherapy, Adjuvant
- DNA, Complementary
- Female
- Follow-Up Studies
- Genes, p53
- Humans
- Lymph Nodes
- Mutation