Article
Inhibition of growth of malignant rat prostate tumor cells by restoration of fibroblast growth factor receptor 2.
Cancer research - 1 Apr 1998
Matsubara A, Kan M, Feng S, McKeehan W L
Abstract excerpt
A loss of expression of fibroblast growth factor (FGF) receptor 2 IIIb (FGFR2IIIb), which responds to stroma-derived FGF, accompanies progression of premalignant androgen-responsive rat prostate tumor epithelial cells to the malignant phenotype. Concurrently, the level of FGFR2 gene expression is reduced and lost altogether in over 30% of cells, whereas all malignant cells abnormally express FGFR1, which is...
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